Description

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You can learn more about CIRS, here. You can find CIRS bloodwork testing, here. 

The Shoemaker CIRS Gene Expression  Inflammation Explained (GENIE) Test is a specialized test designed to better understand Chronic Inflammatory Response Syndrome (CIRS), which can occur after exposure to environmental toxins like mold. The GENIE test looks at gene expression to see how certain genes are turned on or off in response to these toxins. Examining these genetic responses provides insights into the ongoing inflammatory processes in the body, helping to understand how CIRS affects an individual’s health at a molecular level.
The GENIE tests helps to understand how the body’s genetic switches are responding and what may be the source of chronic inflammation and illness. The test is intended to differentiate between mold (mycotoxins, fragments and particles), endotoxins and Actinomycetes. It may also share clues of certail Lyme illness conditions, histamines and PTSD.

The following areas of gene expression are tested:

• Metabolism and hypometabolism: Ratio for metabolic gene families compared to normal controls
• Insulin: The system that controls circulating blood sugar as well as sugar entry into the cell including binding proteins, receptors, and growth factors
• Apoptosis: Can be triggered by mild cellular injury and by various factors internal or external to the cell; the damaged cells are then disposed of in an orderly fashion
• Coagulation: Also known as clotting. The process by which blood changes from a liquid to a gel-forming a blood clot, which potentially results in hemostasis
• Cytokines: Signaling molecules that direct immune function
• Lyme: These genes were found to be changed in patients with acute and post-antibiotics Lyme disease
• GZMS/DEF: Granzymes are proteases used by NK and Cytotoxic T cells to destroy unhealthy cells. Defensins are antimicrobial peptides
• Ikaros: A family of transcription factors important for lymphocyte proliferation and senescence.
• MAP Kinase: MAPKs are involved in directing cellular responses to a diverse array of stimuli
• Toll Receptors: Membrane receptors important in recognition of microorganisms
• B Cells: Most often associated with antibody production
• T Cells: Most often associated with cell to cell combat and immunosynapse with APCs
• CIRS Biomarkers – UP: Genes important to CIRS typically found upregulated
• CIRS Biomarkers: Genes important to CIRS
• PTSD: Post traumatic stress disorder
• Histamine: Inflammatory vasodilator
• Cytoskeleton: Interlinking protein filaments that support cellular structure
• Treg: Regulatory T cell membrane receptors

This information helps doctors and researchers better understand the complexities of CIRS and tailor treatments to address the specific ways your body is being impacted by the condition.

Bloodwork and functional tests focus on identifying the presence of environmental toxins or measuring general inflammatory markers, which may not fully capture the complexity of CIRS, especially when you are stuck.

One of the key benefits of the GENIE test is its ability to identify which genes are being upregulated or downregulated due to exposure to environmental toxins. This information can reveal whether certain immune pathways are overactive or suppressed, which can help in understanding the specific mechanisms driving the patient’s symptoms. By uncovering these genetic patterns, you can find more targeted and effective treatment plans. This genetic insight can help in tracking the effectiveness of treatments over time, providing a valuable tool for ongoing care and adjustment of therapeutic strategies.

We recommend NwJ’s flagship Symptom Burden Assessment (SBA) with any CIRS testing as this has been most effective in getting to root cause healing. 

While there is a lot of new information about Chronic Inflammatory Response Syndrome, if you work with the NwJ team, you will be provided with CIRS resources and support through the protocol together. 

Once you purchase this test review, you will receive instructions on the next steps.